from tkinter import *
root = Tk()
root.title('Test')
def change_text():
print(my_label)
my_label.config(text='new text')
my_label.grid(row=0, column=0)
# create
my_label = Label(root, text='Hello World')
my_button = Button(root, text='click me', command=change_text, bg='#FFFF00')
# draw
my_label.grid()
my_button.grid()
# run
root.mainloop()