string fileLocation = Environment.GetFolderPath(Environment.SpecialFolder.MyDocuments) + Path.DirectorySeparatorChar + "somefile.jpg";
NameValueCollection values = new NameValueCollection();
NameValueCollection files = new NameValueCollection();
values.Add("firstName", "Alan");
files.Add("profilePicture", fileLocation);
sendHttpRequest("http://example.com/handler.php", values, files);