df.loc[:, df.columns != 'b']
a c d
0 0.561196 0.013768 0.772827
1 0.882641 0.615396 0.075381
2 0.368824 0.651378 0.397203
3 0.788730 0.568099 0.869127>>> df
a b c d
0 0.175127 0.191051 0.382122 0.869242
1 0.414376 0.300502 0.554819 0.497524
2 0.142878 0.406830 0.314240 0.093132
3 0.337368 0.851783 0.933441 0.949598
>>> df.drop('b', axis=1)
a c d
0 0.175127 0.382122 0.869242
1 0.414376 0.554819 0.497524
2 0.142878 0.314240 0.093132
3 0.337368 0.933441 0.949598