# Pandas group by a column looking at the count unique/count distinct values of another column
df.groupby('param')['group'].nunique()
df = df.groupby(by='domain', as_index=False).agg({'ID': pd.Series.nunique})
print(df)
domain ID
0 fb 1
1 ggl 1
2 twitter 2
3 vk 3
ID, domain
123, 'vk.com'
123, 'vk.com'
123, 'twitter.com'
456, 'vk.com'
456, 'facebook.com'
456, 'vk.com'
456, 'google.com'
789, 'twitter.com'
789, 'vk.com'