from win32com.client import Dispatch
xl = Dispatch("Excel.Application")
xl.Visible = True # otherwise excel is hidden
# newest excel does not accept forward slash in path
wb = xl.Workbooks.Open(r'C:Users300231823DesktopGUIsimplenew4.xls')
wb.Close()
xl.Quit()
#Creating the ExcelFile object
xls = pd.ExcelFile(r'Path.xlsx')
#In the next step, you can pass the ExcelFile object to read_excel to import
#its content, instead of the path to the file.
data = pd.read_excel(xls, sheet_name='Name_of_sheet', index_col='Index_Column')