>>> df = pd.DataFrame([[1, 2], [3, 4]], columns=list('AB')) >>> df A B 0 1 2 1 3 4 >>> df2 = pd.DataFrame([[5, 6], [7, 8]], columns=list('AB')) >>> df.append(df2) A B 0 1 2 1 3 4 0 5 6 1 7 8