CODE EXAMPLE FOR PYTHON

groupby fillna

In [2400]: df
Out[2400]:
   A  B  C    D
0  1  1  1  1.0
1  1  1  1  NaN
2  1  1  1  3.0
3  3  3  3  5.0

In [2401]: df['D'].fillna(df.groupby(['A','B','C'])['D'].transform('mean'))
Out[2401]:
0    1.0
1    2.0
2    3.0
3    5.0
Name: D, dtype: float64

In [2402]: df['D'] = df['D'].fillna(df.groupby(['A','B','C'])['D'].transform('mean'))

In [2403]: df
Out[2403]:
   A  B  C    D
0  1  1  1  1.0
1  1  1  1  2.0
2  1  1  1  3.0
3  3  3  3  5.0