fig.subplots_adjust(hspace=.5)
import matplotlib.pyplot as plt
matplotlib.pyplot.subplots_adjust(wspace=X, hspace=Y)
# Adjust X for width between subplots
# Adjust Y for height between subplots
import matplotlib.pyplot as plt
fig, axes = plt.subplots(nrows=4, ncols=4)
fig.tight_layout() # Or equivalently, "plt.tight_layout()"
plt.show()