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all column except pandas

df[df.columns.difference(['b'])]

Out: 
          a         c         d
0  0.427809  0.459807  0.333869
1  0.678031  0.668346  0.645951
2  0.996573  0.673730  0.314911
3  0.786942  0.719665  0.330833
Comment

select all columns except one pandas

df[df.columns.drop('b')]
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